EyePromise Science Summary

Since 2001, EyePromise has been dedicated to fighting age-related eye health issues through science-based nutraceuticals. To date, more than 300 published studies exist on nutrition, macular pigment, and the impact on eye health.
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Age-Related Eye Health Issues & Macular Pigments:
(Zeaxanthin and Lutein)
AREDS 2 Study
• The AREDS 1 formula plus Lutein & Zeaxanthin vs. AREDS 1 & beta-carotene:
– 18% reduction in the progression to advanced age-related eye health issues
– 22% reduction in the risk of progression to neovascular age-related eye health issues
• AREDS formula along with Lutein + Zeaxanthin vs. AREDS formula with no Lutein + Zeaxanthin:
– 10% additional reduction in the risk of progression to advanced age-related eye health issues
– 11% reduction in the risk of progression to neovascular age-related eye health issues
– 26% reduction to advanced age-related eye health issues in the lowest quintile – the group with the lowest dietary intake of Lutein and Zeaxanthin, which is more representative of the general population
Improvement of Retinal Function in Early Age-Related Eye Health Issues After Lutein and Zeaxanthin Supplementation: A Randomized, Double-Masked, Placebo-Controlled Trial
(Ma et. al. – American Journal of Ophthalmology, October 2012, Peking University Eye Center, Beijing, China)
• 108 subjects with early age-related eye health issues supplemented with 10mg Lutein, 10mg Lutein & 10mg Zeaxanthin, 20mg Lutein, or placebo plus 36 age matched controls. (144 subjects)
• Pre and post supplementation multi-focal ERG was measured in 6 concentric annular zones around the macula
• Increased MPOD related positively to increases in N1P1 response density in ring 1 and ring 2 with little effect in ring 3 thru 6
• Improvement of N1P1 response densities was positively associated with MPOD increase, suggesting a causative effect of MPOD on retinal function and health
• Early functional abnormalities of the central retina in the early age-related eye health issues patients may be improved by Lutein and Zeaxanthin supplementation
• The 10mg Lutein/10mg dietary Zeaxanthin arm had the greatest ERG documented retinal function increase in ring 1.
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