EyePromise Science Summary

(Zeaxanthin and Lutein)

AREDS 2 Study

• The AREDS 1 formula plus Lutein & Zeaxanthin vs. AREDS 1 & beta-carotene:

– 18% reduction in the progression to advanced age-related eye health issues

– 22% reduction in the risk of progression to neovascular age-related eye health issues

• AREDS formula along with Lutein + Zeaxanthin vs. AREDS formula with no Lutein + Zeaxanthin:

– 10% additional reduction in the risk of progression to advanced age-related eye health issues

– 11% reduction in the risk of progression to neovascular age-related eye health issues

– 26% reduction to advanced age-related eye health issues in the lowest quintile – the group with the lowest dietary intake of Lutein and Zeaxanthin, which is more representative of the general population

Improvement of Retinal Function in Early Age-Related Eye Health Issues After Lutein and Zeaxanthin Supplementation: A Randomized, Double-Masked, Placebo-Controlled Trial

(Ma et. al. – American Journal of Ophthalmology, October 2012, Peking University Eye Center, Beijing, China)

• 108 subjects with early age-related eye health issues supplemented with 10mg Lutein, 10mg Lutein & 10mg Zeaxanthin, 20mg Lutein, or placebo plus 36 age matched controls. (144 subjects)

• Pre and post supplementation multi-focal ERG was measured in 6 concentric annular zones around the macula

• Increased MPOD related positively to increases in N1P1 response density in ring 1 and ring 2 with little effect in ring 3 thru 6

• Improvement of N1P1 response densities was positively associated with MPOD increase, suggesting a causative effect of MPOD on retinal function and health

• Early functional abnormalities of the central retina in the early age-related eye health issues patients may be improved by Lutein and Zeaxanthin supplementation

• The 10mg Lutein/10mg dietary Zeaxanthin arm had the greatest ERG documented retinal function increase in ring 1.


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